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[DOI] [PMC free article] [PubMed] [Google Scholar] 834.Tang T, Wang LX, Yang ML, Zhang RM

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These mtROS suppress autophagic clearance by oxidatively inactivating the IRS-1/PI3K pathway [413], while simultaneously activating HIF-1 to promote glycolysis, creating a nutrient-rich microenvironment for MTB

Bioavailability via the subcutaneous route is estimated at 60-80% based on analogous GH-axis peptide data, though no dedicated human bioavailability study for IGF-1 LR3 specifically has been published in peer-reviewed literature [1]